Structural biology: How opioid drugs bind to receptors

Nature. 2012 May 16;485(7398):314-7. doi: 10.1038/485314a.

Abstract

The search for safe, non-addictive versions of morphine and other opioid drugs has just received a boost with the solving of the crystal structures of the receptors to which the drugs bind.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Biomimetic Materials / chemistry*
  • Humans
  • Morphinans / chemistry*
  • Naltrexone / analogs & derivatives*
  • Naltrexone / chemistry
  • Opioid Peptides / chemistry*
  • Piperidines / chemistry*
  • Piperidines / metabolism*
  • Receptors, Opioid / chemistry*
  • Receptors, Opioid / metabolism*
  • Receptors, Opioid, delta / chemistry*
  • Receptors, Opioid, kappa / antagonists & inhibitors*
  • Receptors, Opioid, kappa / chemistry*
  • Receptors, Opioid, mu / antagonists & inhibitors*
  • Receptors, Opioid, mu / chemistry*
  • Spiro Compounds / chemistry*
  • Spiro Compounds / metabolism*
  • Tetrahydroisoquinolines / chemistry*

Substances

  • (Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)
  • 1-benzyl-N-(3-(spiroisobenzofuran-1(3H),4'-piperidin-1-yl)propyl)pyrrolidine-2-carboxamide
  • 7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
  • Morphinans
  • Opioid Peptides
  • Piperidines
  • Receptors, Opioid
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu
  • Spiro Compounds
  • Tetrahydroisoquinolines
  • Naltrexone
  • nociceptin receptor
  • naltrindole