Filamentous bacteriophage fd as an antigen delivery system in vaccination

Int J Mol Sci. 2012;13(4):5179-94. doi: 10.3390/ijms13045179. Epub 2012 Apr 24.

Abstract

Peptides displayed on the surface of filamentous bacteriophage fd are able to induce humoral as well as cell-mediated immune responses, which makes phage particles an attractive antigen delivery system to design new vaccines. The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205. Here, we review recent advances in the use of filamentous phage fd as a platform for peptide vaccines, with a special focus on the use of phage fd as an antigen delivery platform for peptide vaccines in Alzheimer's Disease and cancer.

Keywords: antigen delivery system; bacteriophage fd; vaccine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid beta-Peptides / immunology
  • Animals
  • Bacteriophage M13 / immunology*
  • Capsid / immunology
  • Capsid / metabolism
  • Capsid Proteins / immunology*
  • Capsid Proteins / metabolism
  • Cell Surface Display Techniques / methods*
  • Dendritic Cells / immunology
  • Drug Carriers / administration & dosage*
  • Mice
  • Peptide Library
  • T-Lymphocytes, Cytotoxic / immunology
  • Vaccination / methods
  • Vaccines, Subunit / administration & dosage
  • Vaccines, Subunit / immunology*

Substances

  • Amyloid beta-Peptides
  • Capsid Proteins
  • Drug Carriers
  • Peptide Library
  • Vaccines, Subunit
  • coat protein, Bacteriophage M13