A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children

ScientificWorldJournal. 2012:2012:810234. doi: 10.1100/2012/810234. Epub 2012 Apr 19.


Introduction: Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children.

Methods: Sixty-six infants with DD (aged < 3 years) were randomized to receive either aloe cream (n = 32) or Calendula ointment (n = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial.

Results: Although improvement in the severity of DD was observed in both treatment groups (P < 0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to aloe group (P = 0.001). No adverse effect was reported from either of the medications.

Discussion: The evidence from this study suggests that topical aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Aloe / chemistry*
  • Calendula / chemistry*
  • Child, Preschool
  • Diaper Rash / drug therapy*
  • Double-Blind Method
  • Drug Administration Schedule
  • Emulsions / administration & dosage
  • Emulsions / chemistry
  • Emulsions / therapeutic use
  • Female
  • Flowers / chemistry
  • Humans
  • Infant
  • Male
  • Ointments / administration & dosage
  • Ointments / therapeutic use
  • Olive Oil
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use
  • Plant Oils / administration & dosage
  • Plants, Medicinal / chemistry
  • Prevalence
  • Severity of Illness Index


  • Emulsions
  • Ointments
  • Olive Oil
  • Plant Extracts
  • Plant Oils