Unusual manifestations of acute Q fever: autoimmune hemolytic anemia and tubulointerstitial nephritis

Ann Clin Microbiol Antimicrob. 2012 May 18;11:14. doi: 10.1186/1476-0711-11-14.


Q fever is a worldwide zoonotic infection that caused by Coxiella burnetii, a strict intracellular bacterium. It may be manifested by some of the autoimmune events and is classified into acute and chronic forms. The most frequent clinical manifestation of acute form is a self-limited febrile illness which is associated with severe headache, muscle ache, arthralgia and cough. Meningoencephalitis, thyroiditis, pericarditis, myocarditis, mesenteric lymphadenopathy, hemolytic anemia, and nephritis are rare manifestations. Here we present a case of acute Q fever together with Coombs' positive autoimmune hemolytic anemia (AIHA) and tubulointerstitial nephritis treated with chlarithromycin, steroids and hemodialysis. Clinicians should be aware of such rare manifestations of the disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Hemolytic, Autoimmune / diagnosis*
  • Anemia, Hemolytic, Autoimmune / microbiology
  • Anemia, Hemolytic, Autoimmune / therapy
  • Clarithromycin / therapeutic use
  • Coombs Test
  • Coxiella burnetii / pathogenicity*
  • Coxiella burnetii / physiology
  • Humans
  • Male
  • Methylprednisolone / therapeutic use
  • Nephritis, Interstitial / diagnosis*
  • Nephritis, Interstitial / microbiology
  • Nephritis, Interstitial / therapy
  • Q Fever / diagnosis*
  • Q Fever / microbiology
  • Q Fever / therapy
  • Renal Dialysis


  • Clarithromycin
  • Methylprednisolone