The association between the triglyceride to high-density lipoprotein cholesterol ratio with insulin resistance (HOMA-IR) in the general Korean population: based on the National Health and Nutrition Examination Survey in 2007-2009

Diabetes Res Clin Pract. 2012 Jul;97(1):132-8. doi: 10.1016/j.diabres.2012.04.022. Epub 2012 May 18.


Aims: This study explores the association between the ratio of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) and insulin resistance according to waist circumference in the general Korean population.

Methods: 7623 participants were selected from the Korean National Health and Nutrition Examination Survey (KNHANES) conducted during 2007-2009 and included in this cross-sectional study. Insulin resistance was defined as the values equal to or greater than the 75th percentile of the homeostasis model assessment of insulin resistance (HOMA-IR).

Results: Positive correlation was found between the ratio of TG and HDL-C and other variables such as waist circumference, total cholesterol, and HOMA-IR for both men and women. The odds ratios (ORs) (95% confidence interval) for insulin resistance for the highest quartile of TG/HDL-C were 2.48 in men and 3.05 in women. The significant relationship between the TG/HDL-C ratio and insulin resistance was not only maintained across all quartiles of waist circumference but also seemed to be enhanced in the higher quartiles of waist circumference.

Conclusion: In the general Korean population, there seems to be a linear association between TG/HDL-C ratio and insulin resistance, regardless of degrees of waist circumference.

MeSH terms

  • Asian Continental Ancestry Group*
  • Blood Pressure
  • Cholesterol, HDL / blood*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Insulin Resistance*
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Obesity / epidemiology
  • Republic of Korea / epidemiology
  • Triglycerides / blood*
  • Waist Circumference*


  • Cholesterol, HDL
  • Triglycerides