Use of blood polymerase chain reaction testing for diagnosis of herpes simplex virus infection

J Pediatr. 2012 Aug;161(2):357-61. doi: 10.1016/j.jpeds.2012.04.009. Epub 2012 May 19.


The use of herpes simplex virus (HSV) polymerase chain reaction for diagnosis of HSV disease involving the central nervous system has not translated into widespread use for the detection of DNAemia. We report our 6-year experience using blood polymerase chain reaction testing for HSV infection in neonates and older children with HSV disease.

MeSH terms

  • Adolescent
  • Central Nervous System Viral Diseases / diagnosis
  • Child
  • Child, Preschool
  • DNA, Viral / blood*
  • Female
  • Herpes Simplex / diagnosis*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Polymerase Chain Reaction*
  • Simplexvirus / isolation & purification*


  • DNA, Viral