Patients with oral cancer, undergoing ablative surgery, were left with severe deformities and dysfunction. Although the defect can be repaired by flap transplantation, there were still difficulties to restore normal oral structure and function of the oral cavity. In these instances, rehabilitation of mastication and occlusion is of the utmost importance. This article described the procedure that implants were inserted and bar/clips retained overdenture was applied to a patient who underwent reconstruction with pectoralis major myocutaneous flap after cancer ablation surgery. The patient's oral structure and functions was recovered, and the quality of life was greatly improved.