Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats

Exp Diabetes Res. 2012;2012:316384. doi: 10.1155/2012/316384. Epub 2012 Apr 26.


Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Caspase 3 / metabolism*
  • Diabetes Mellitus, Experimental / metabolism*
  • Endothelium, Vascular / metabolism
  • Erythrocyte Count
  • Erythrocytes / metabolism*
  • Female
  • Lipid Peroxidation / physiology
  • Oxidative Stress / physiology
  • Rats
  • Rats, Wistar


  • Caspase 3