Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients

Gynecol Endocrinol. 2012 Dec;28(12):969-73. doi: 10.3109/09513590.2012.685205. Epub 2012 May 21.

Abstract

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, chronic anovulation, polycystic ovaries at ultrasound evaluation, and quite frequently by insulin resistance or compensatory hyperinsulinemia. Attention has been given to the role of inositol-phosphoglycan (IPG) mediators of insulin action and growing evidences suggest that a deficiency of D-chiro-inositol (DCI) containing IPG might be at the basis of insulin resistance, frequent in PCOS patients. On such basis, we investigated the efficacy on insulin sensitivity and hormonal parameters of 8 weeks treatment with myo-inositol (MYO) (Inofert, ItalPharmaco, Milano, Italy) at the dosage of 2 g day in a group (n = 42) of obese PCOS patients,. After the treatment interval body mass index (BMI) and insulin resistance decreased together with luteinizing hormone (LH), LH/FSH and insulin. When subdividing the patients according to their fasting insulin levels, Group A (n = 15) insulin below 12 µU/ml and Group B (n = 27) insulin above 12 µU/ml, MYO treatment induced similar changes in both groups but only patients of Group B showed the significant decrease of both fasting insulin plasma levels (from 20.3 ± 1.8 to 12.9 ± 1.8 µU/ml, p < 0.00001) and of area under the curve (AUC) of insulin under oral glucose tolerance test (OGTT). In conclusion, our study supports the hypothesis that MYO administration is more effective in obese patients with high fasting insulin plasma levels.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Body Mass Index
  • Dietary Supplements*
  • Female
  • Folic Acid / therapeutic use
  • Follicle Stimulating Hormone / blood
  • Glucose Tolerance Test
  • Humans
  • Hyperinsulinism / etiology
  • Hyperinsulinism / prevention & control*
  • Inositol / deficiency
  • Inositol / therapeutic use*
  • Inositol Phosphates / metabolism
  • Insulin / blood
  • Insulin Antagonists / metabolism
  • Insulin Resistance*
  • Luteinizing Hormone / blood
  • Obesity / complications*
  • Overweight / complications*
  • Polycystic Ovary Syndrome / complications
  • Polycystic Ovary Syndrome / diet therapy*
  • Polycystic Ovary Syndrome / metabolism
  • Polycystic Ovary Syndrome / physiopathology
  • Polysaccharides / metabolism
  • Weight Loss

Substances

  • Inositol Phosphates
  • Insulin
  • Insulin Antagonists
  • Polysaccharides
  • inositol phosphate glycan
  • Inositol
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Folic Acid