Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease

J Clin Neurosci. 2012 Jul;19(7):946-9. doi: 10.1016/j.jocn.2011.12.022. Epub 2012 May 20.


Alzheimer's disease (AD) is one of the most common causes of dementia in the elderly. It is characterized by extracellular deposition of the neurotoxic peptide, amyloid-beta (Aβ) peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. However, the pathogenesis of AD is not fully understood. The aim of this review is to discuss the possible role of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signalling in the development of AD, focusing on BDNF/TrkB signalling in the production of Aβ, tau hyperphosphorylation and cognition decline, and exploring new possibilities for AD intervention.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / complications
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Humans
  • Receptor, trkB / metabolism*
  • Signal Transduction / physiology*


  • Brain-Derived Neurotrophic Factor
  • Receptor, trkB