Real-time stochastic detection of multiple neurotransmitters with a protein nanopore

ACS Nano. 2012 Jun 26;6(6):5304-8. doi: 10.1021/nn301125y. Epub 2012 May 24.


The detection of several different neurotransmitters with the same sensor in real-time would be a powerful asset to the field of neurochemistry. We have developed a detector for a broad range of neurotransmitters including amino acids, catecholamines, and nucleotides, which relies on the reversible binding of the analytes to a copper(II) complex within an engineered protein nanopore.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • Conductometry / methods*
  • Copper / chemistry*
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Neurotransmitter Agents / analysis*
  • Porosity
  • Protein Interaction Mapping / methods*
  • Stochastic Processes


  • Neurotransmitter Agents
  • Copper