Mitotic and mitogenic Wnt signalling

EMBO J. 2012 Jun 13;31(12):2705-13. doi: 10.1038/emboj.2012.124. Epub 2012 May 22.


Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell proliferation by promoting G1 phase. In mitosis, components of the Wnt signalling cascade function directly in spindle formation. Moreover, Wnt signalling is strongly activated in mitosis, suggesting that 'mitotic Wnt signalling' plays an important role to orchestrate a cell division program. Here, we review the complex interplay between Wnt signalling and the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Proliferation*
  • Gene Expression Regulation*
  • Humans
  • Mitosis*
  • Models, Biological
  • Neoplasms / metabolism
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway*


  • Wnt Proteins