Chromatin-remodeling complex specificity and embryonic vascular development

Cell Mol Life Sci. 2012 Dec;69(23):3921-31. doi: 10.1007/s00018-012-1023-4. Epub 2012 May 23.


Vascular development is a dynamic process that relies on the coordinated expression of numerous genes, but the factors that regulate gene expression during blood vessel development are not well defined. ATP-dependent chromatin-remodeling complexes are gaining attention for their specific temporal and spatial effects on gene expression during vascular development. Genetic mutations in chromatin-remodeling complex subunits are revealing roles for the complexes in vascular signaling pathways at discrete developmental time points. Phenotypic analysis of these models at various stages of vascular development will continue to expand our understanding of how chromatin remodeling impacts new blood vessel growth. Such research could also provide novel therapeutic targets for the treatment of vascular pathologies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism
  • Adenosine Triphosphate / metabolism
  • Animals
  • Blood Vessels / embryology
  • Blood Vessels / metabolism*
  • Chromatin / genetics*
  • Chromatin / metabolism
  • Chromatin Assembly and Disassembly*
  • Gene Expression Regulation, Developmental
  • Humans
  • Models, Cardiovascular
  • Neovascularization, Physiologic / genetics*


  • Chromatin
  • Adenosine Triphosphate
  • Adenosine Triphosphatases