Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012;13(5):156.
doi: 10.1186/gb-2012-13-5-156.

Enhancer Dysfunction: How the Main Regulators of Gene Expression Contribute to Cancer

Affiliations
Free PMC article

Enhancer Dysfunction: How the Main Regulators of Gene Expression Contribute to Cancer

Siavash K Kurdistani. Genome Biol. .
Free PMC article

Abstract

A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal gene regulatory DNA sequences in the establishment of an oncogenic transcriptional program.

Similar articles

See all similar articles

Cited by 5 articles

References

    1. Akhtar-Zaidi B, Cowper-Sal Lari R, Corradin O, Saiakhova A, Bartels CF, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady MF, Willis J, Moore JH, Tesar PJ, Laframboise T, Markowitz S, Lupien M, Scacheri PC. Epigenomic enhancer profiling defines a signature of colon cancer. Science. 2012. - DOI - PMC - PubMed
    1. Müller MM, Gerster T, Schaffner W. Enhancer sequences and the regulation of gene transcription. Eur J Biochem. 1988;176:485–495. doi: 10.1111/j.1432-1033.1988.tb14306.x. - DOI - PubMed
    1. Heintzman ND, Hon GC, Hawkins RD, Kheradpour P, Stark A, Harp LF, Ye Z, Lee LK, Stuart RK, Ching CW, Ching KA, Antosiewicz-Bourget JE, Liu H, Zhang X, Green RD, Lobanenkov VV, Stewart R, Thomson JA, Crawford GE, Kellis M, Ren B. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature. 2009;459:108–112. doi: 10.1038/nature07829. - DOI - PMC - PubMed
    1. Ong CT, Corces VG. Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet. 2011;12:283–293. - PMC - PubMed
    1. Jia L, Landan G, Pomerantz M, Jaschek R, Herman P, Reich D, Yan C, Khalid O, Kantoff P, Oh W, Manak JR, Berman BP, Henderson BE, Frenkel B, Haiman CA, Freedman M, Tanay A, Coetzee GA. Functional enhancers at the gene-poor 8q24 cancer-linked locus. PLoS Genet. 2009;5:e1000597. doi: 10.1371/journal.pgen.1000597. - DOI - PMC - PubMed
Feedback