Enhancer dysfunction: how the main regulators of gene expression contribute to cancer

Genome Biol. 2012;13(5):156. doi: 10.1186/gb-2012-13-5-156.


A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal gene regulatory DNA sequences in the establishment of an oncogenic transcriptional program.

MeSH terms

  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / metabolism
  • Enhancer Elements, Genetic / genetics*
  • Gene Expression Profiling / methods
  • Gene Expression*
  • Genome, Human
  • Humans
  • Regulatory Sequences, Nucleic Acid*
  • Transcription, Genetic