Pneumococcal vaccines WHO position paper - 2012 - recommendations

Vaccine. 2012 Jul 6;30(32):4717-8. doi: 10.1016/j.vaccine.2012.04.093. Epub 2012 May 20.


This article presents the World Health Organization (WHO) recommendations on the use of pneumococcal vaccines excerpted from the Pneumococcal vaccines WHO position paper - 2012 recently published in the Weekly Epidemiological Record. The current document replaces the position paper on the use 7-valent pneumococcal conjugate vaccine published in 2007. Incorporating the most recent developments in the field of pneumococcal vaccines this position paper focuses on the currently available 10-valent and 13-valent conjugate vaccines and their introduction and use in national immunization programmes. It also deals with the 23-valent polysaccharide vaccine, though in less detail than provided in the April 2008 position paper which remains valid. Footnotes to this paper provide a number of core references including references to grading tables that assess the quality of scientific evidence for a few key conclusions. In accordance with its mandate to provide guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers on vaccines and combinations of vaccines against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes; they summarize essential background information on diseases and vaccines, and conclude with WHO's current position on the use of vaccines worldwide. This paper reflects the recommendations of the WHO's Strategic Advisory Group of Experts (SAGE) on immunization. Recommendations on the use of pneumococcal vaccines were discussed by SAGE at its meetings in November 2006 (conjugate vaccine) and April 2008 (polysaccharide vaccine) and most recently in November 2011. Evidence presented at these meetings can be accessed at

MeSH terms

  • Guidelines as Topic*
  • Humans
  • Immunization Programs*
  • Immunization Schedule
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines*
  • Sentinel Surveillance
  • Vaccines, Conjugate
  • World Health Organization*


  • 10-valent pneumococcal vaccine
  • 13-valent pneumococcal vaccine
  • 23-valent pneumococcal capsular polysaccharide vaccine
  • Pneumococcal Vaccines
  • Vaccines, Conjugate