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. 2010 Feb;2(2):81-6.
doi: 10.4297/najms.2010.281.

Effect of Curcumin on Quinpirole Induced Compulsive Checking: An Approach to Determine the Predictive and Construct Validity of the Model

Free PMC article

Effect of Curcumin on Quinpirole Induced Compulsive Checking: An Approach to Determine the Predictive and Construct Validity of the Model

Jithendra Chimakurthy et al. N Am J Med Sci. .
Free PMC article


Background: Disorders of anxiety vary in severity to a wide extent, and obsessive-compulsive disorder (OCD) persists as the fourth most common form of mental illness and is reported to be associated with memory impairment, necessitating effective means of treatment.

Aim: To study the effect of curcumin on OCD.

Methods: The present study includes the determination of effect of curcumin at 5 and 10 mg/kg in quinpirole (0.5 mg/kg) -induced model of OCD, memory retention and brain monoamine levels in rats.

Results: A significant improvement from the obsessive-compulsive symptoms induced by quinpirole was observed in curcumin treated rats; curcumin showed a protective effect on memory task. An increase in serotonin levels and a decrease in the dopamine levels were observed in curcumin treated rats.

Conclusion: Curcumin treatment had shown a protective effect in OCD with considerable influence on brain monoamine levels, thus providing an evidence for the predictive and construct validity of the model.

Keywords: Obsessive-compulsive disorder; curcumin; dopamine; quinpirole; serotonin; water maze apparatus.


Fig 1
Fig 1
Number of visits to other objects on successive return to each object. N and Y indicate nonsignificant and significant differences, respectively, obtained by one sample t test comparision (n=6) of number of visits on successive return to the object with that of the object where less number of visits on successive return are shown.
Fig 2
Fig 2
Effect on retention of learned task: the delay in time to reach the escape platform from the starting point on the last day of treatment after exploration on open field, each column represents mean ± SEM (n=6) of time taken by the rats to reach the escape platform from the starting point, Values of values of curcumin 5, 10 mg/kg and paroxetine treated were compared with that of quinpirole treated negative control rats. # p<0.001, ** p<0.01, * p<0.05.
Fig 3
Fig 3
Dopamine and serotonin levels of whole brain: the effect of curcumin and paroxetine on dopamine and serotonin levels (nanogram/gram of wet tissue) in rat brain. Each column represents the mean ± SEM (n=6). Values of control, curcumin 5mg/kg, curcumin and paroxetine treated rats were compared with negative control. All the groups except control were treated with quinpirole. # p<0.001, ** p<0.01, * p<0.05, ns – non significant.

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