SMIP-016 in action: CD37 as a death receptor

Lei Jin; John C Cambier

doi:10.1016/j.ccr.2012.04.034

SMIP-016 in action: CD37 as a death receptor

Cancer Cell. 2012 May 15;21(5):597-598. doi: 10.1016/j.ccr.2012.04.034.

Authors

Lei Jin¹, John C Cambier²

Affiliations

¹ Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, Denver, CO 80206, USA.
² Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, Denver, CO 80206, USA. Electronic address: cambierj@njhealth.org.

Abstract

CD37 is a tetraspannin that triggers cell death and is a potential therapeutic target in cancers. In this issue of Cancer Cell, Lapalombella et al. show that CD37 is tyrosine phosphorylated following engagement by a bivalent engineered antibody fragment that binds CD37 and activates both SHP-1-dependent apoptotic signaling and PI3K-AKT-mediated survival signaling.

Publication types

Comment

Grants and funding

T32 AI074491/AI/NIAID NIH HHS/United States