Hortonones A to C, hydroazulenones from the genus Hortonia

Gavin Carr; David E Williams; Rukmal Ratnayake; Ratnayake Bandara; Siril Wijesundara; Tamsin Tarling; Aruna D Balgi; Michel Roberge; Raymond J Andersen; Veranja Karunaratne

doi:10.1021/np200927k

Hortonones A to C, hydroazulenones from the genus Hortonia

J Nat Prod. 2012 Jun 22;75(6):1189-91. doi: 10.1021/np200927k. Epub 2012 May 24.

Authors

Gavin Carr¹, David E Williams, Rukmal Ratnayake, Ratnayake Bandara, Siril Wijesundara, Tamsin Tarling, Aruna D Balgi, Michel Roberge, Raymond J Andersen, Veranja Karunaratne

Affiliation

¹ Department of Chemistry and Earth, University of British Columbia, Vancouver, British Columbia, Canada.

PMID: 22626446
DOI: 10.1021/np200927k

Abstract

The new hexahydroazulenones hortonones A (1) to C (3) were isolated from the leaves of three representative species of the endemic Sri Lankan genus Hortonia that belongs to the family Monimiaceae. Hortonones A (1) and B (2) have the unprecedented rearranged hortonane sesquiterpenoid carbon skeleton, and hortonone C (3) has the unprecedented rearranged and degraded 13-norhortonane skeleton. Hortonone C (3) exhibited in vitro cytotoxicity against human breast cancer MCF-7 cells at 5 μg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Breast Neoplasms
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Female
Humans
Molecular Structure
Monimiaceae / chemistry*
Plant Leaves / chemistry
Sri Lanka

Substances

Antineoplastic Agents, Phytogenic
Diterpenes
hortonone A
hortonone B
hortonone C