Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy

Adv Drug Deliv Rev. 2013 May;65(5):744-55. doi: 10.1016/j.addr.2012.05.007. Epub 2012 May 22.


Lanthanide-doped upconverting luminescent nanoparticles (UCNPs) are promising materials for optical imaging-guided drug delivery and therapy due to their unique optical and chemical properties. UCNPs absorb low energy near-infrared (NIR) light and emit high-energy shorter wavelength photons. Their special features allow them to overcome various problems associated with conventional imaging probes and to provide versatility for creating nanoplatforms with both imaging and therapeutic modalities. Here, we discuss several approaches to fabricate and utilize UCNPs for traceable drug delivery and therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / methods*
  • Humans
  • Lanthanoid Series Elements* / administration & dosage
  • Luminescence
  • Luminescent Agents* / administration & dosage
  • Nanoparticles* / administration & dosage
  • Optical Imaging / methods*


  • Lanthanoid Series Elements
  • Luminescent Agents