Functions of plasmalogen lipids in health and disease

Biochim Biophys Acta. 2012 Sep;1822(9):1442-52. doi: 10.1016/j.bbadis.2012.05.008. Epub 2012 May 22.


Plasmalogens are a unique class of membrane glycerophospholipids containing a fatty alcohol with a vinyl-ether bond at the sn-1 position, and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone. These two features provide novel properties to these compounds. Although plasmalogens represent up to 20% of the total phospholipid mass in humans their physiological roles have been challenging to identify, and are likely to be particular to different tissues, metabolic processes and developmental stages. Their biosynthesis starts in peroxisomes, and defects at these steps cause the malformation syndrome, Rhizomelic Chondrodysplasia Punctata (RCDP). The RCDP phenotype predicts developmental roles for plasmalogens in bone, brain, lens, lung, kidney and heart. Recent studies have revealed secondary plasmalogen deficiencies associated with more common disorders and allow us to tease out additional pathways dependent on plasmalogen functions. In this review, we present current knowledge of plasmalogen biology in health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Animals
  • Biological Transport
  • Cell Membrane / metabolism
  • Glyceryl Ethers / therapeutic use
  • Humans
  • Lipid Metabolism
  • Organ Specificity
  • Oxidation-Reduction
  • Peroxisomal Disorders / drug therapy
  • Peroxisomal Disorders / metabolism*
  • Plasmalogens / biosynthesis
  • Plasmalogens / metabolism
  • Plasmalogens / physiology*
  • Respiratory Tract Diseases / metabolism
  • Signal Transduction


  • Glyceryl Ethers
  • Plasmalogens
  • batyl alcohol