Inflammatory markers in coronary artery disease

Biofactors. Sep-Oct 2012;38(5):320-8. doi: 10.1002/biof.1024. Epub 2012 May 24.

Abstract

Coronary artery disease (CAD) is one of the most common manifestations of atherosclerosis. Inflammation is considered one of the major processes that contribute to atherogenesis. Inflammation plays an important role not only on the initiation and progression of atherosclerosis but also on plaque rupture, an event that leads to acute vascular events. Various biomarkers express different pathways and pathophysiologic mechanisms of cardiovascular disease, and inflammatory biomarkers express different parts of the atherogenic process, regarding the initiation and progression of atherosclerosis or the destabilization of the atherosclerotic plaque. Therefore, inflammatory biomarkers may prove to be useful in the detection, staging, and prognosis of patients with CAD. Furthermore, the fact that inflammatory processes are essential steps in the course of the disease offers future therapeutic targets for the interruption of the atherogenic process or for the management of acute events.

Publication types

  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / blood
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Atherosclerosis / blood*
  • Atherosclerosis / complications
  • Atherosclerosis / physiopathology
  • Atherosclerosis / prevention & control
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / complications
  • Coronary Artery Disease / physiopathology
  • Coronary Artery Disease / prevention & control
  • Coronary Vessels / metabolism
  • Coronary Vessels / physiopathology
  • Cytokines / blood
  • Disease Progression
  • Humans
  • Inflammation / blood*
  • Inflammation / complications
  • Inflammation / physiopathology
  • Inflammation / prevention & control
  • Leukocyte Count
  • Leukocytes / immunology
  • Leukocytes / pathology
  • Nitric Oxide Synthase Type II / blood

Substances

  • Anti-Inflammatory Agents
  • Biomarkers
  • Cytokines
  • C-Reactive Protein
  • NOS2 protein, human
  • Nitric Oxide Synthase Type II
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase