Soluble urokinase plasminogen activator receptor in patients with abdominal aortic aneurysm

Thromb Res. 2012 Sep;130(3):511-3. doi: 10.1016/j.thromres.2012.05.007. Epub 2012 May 26.

Abstract

Introduction: In the present study we investigated the impact of soluble urokinase plasminogen activator receptor (suPAR) as a biomarker in patients with abdominal aortic aneurysm (AAA) in relation to conventional inflammatory markers, aneurysm size, and rupture.

Methods: suPAR and conventional inflammatory markers were measured in 119 patients with AAA and 36 controls without aneurysm matched by age, gender and smoking habit.

Results: The results support earlier studies suggesting a state of activated inflammatory response in patients with nonruptured AAA as expressed by elevated CRP and IL-6 compared with the controls. In contrast, suPAR showed similar levels in patients with nonruptured AAA compared with the controls. Unexpectedly, all follow-up patients (n=16) have significant (p<0.001) elevated suPAR levels three years postoperatively compared preoperatively.

Conclusions: suPAR does not seem to be a useful biomarker in the AAA disease. The role of the postoperative elevation of suPAR needs to be further elucidated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aortic Aneurysm, Abdominal / blood
  • Aortic Aneurysm, Abdominal / enzymology*
  • Aortic Aneurysm, Abdominal / epidemiology*
  • Biomarkers / blood
  • Biomarkers / chemistry
  • Female
  • Humans
  • Male
  • Prevalence
  • Receptors, Urokinase Plasminogen Activator / blood*
  • Receptors, Urokinase Plasminogen Activator / chemistry
  • Reproducibility of Results
  • Risk Assessment
  • Sensitivity and Specificity
  • Solubility
  • Sweden

Substances

  • Biomarkers
  • PLAUR protein, human
  • Receptors, Urokinase Plasminogen Activator