Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women

Fertil Steril. 2012 Aug;98(2):396-400. doi: 10.1016/j.fertnstert.2012.05.003. Epub 2012 May 24.

Abstract

Objective: To investigate the role of glutathione S-transferases (GSTs) in the pathogenesis of recurrent miscarriage (RM).

Design: Genetic association study.

Setting: University of Rome, Tor Vergata and San Giovanni Calibita, Fatebenefratelli Hospital.

Patient(s): One hundred twenty-one women with RM and 113 women without pregnancy complications.

Intervention(s): Genomic DNA extracted from buccal cells and screening of positive/null genotypes of GSTM1 and GSTT1 genes and single nucleotide polymorphisms of GSTA1, GSTO2, and GSTP1 genes.

Main outcome measure(s): Occurrence of GST polymorphisms.

Result(s): Women with at least one GSTA1*-69T allele are more frequent in the RM group than in the control group: 67% vs. 48%, respectively. Significant outcomes were obtained considering different genetic models: codominant, dominant, and log-additive. In addition, the combined analysis suggests that GSTA1 and GSTM1 variants have a significant interaction in RM risk.

Conclusion(s): Our study highlighted a significant association between the GSTA1 gene and an increased risk of RM. In particular, the -69T allele in the GSTA1 gene may be considered as a predisposing factor of RM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / enzymology
  • Abortion, Habitual / epidemiology*
  • Abortion, Habitual / genetics*
  • Adult
  • Female
  • Gene Frequency / genetics
  • Genetic Association Studies / methods*
  • Glutathione Transferase / genetics*
  • Humans
  • Italy / epidemiology
  • Middle Aged
  • Pregnancy
  • Risk Factors
  • Young Adult

Substances

  • GSTA1 protein, human
  • Glutathione Transferase