Objective: To investigate the role of glutathione S-transferases (GSTs) in the pathogenesis of recurrent miscarriage (RM).
Design: Genetic association study.
Setting: University of Rome, Tor Vergata and San Giovanni Calibita, Fatebenefratelli Hospital.
Patient(s): One hundred twenty-one women with RM and 113 women without pregnancy complications.
Intervention(s): Genomic DNA extracted from buccal cells and screening of positive/null genotypes of GSTM1 and GSTT1 genes and single nucleotide polymorphisms of GSTA1, GSTO2, and GSTP1 genes.
Main outcome measure(s): Occurrence of GST polymorphisms.
Result(s): Women with at least one GSTA1*-69T allele are more frequent in the RM group than in the control group: 67% vs. 48%, respectively. Significant outcomes were obtained considering different genetic models: codominant, dominant, and log-additive. In addition, the combined analysis suggests that GSTA1 and GSTM1 variants have a significant interaction in RM risk.
Conclusion(s): Our study highlighted a significant association between the GSTA1 gene and an increased risk of RM. In particular, the -69T allele in the GSTA1 gene may be considered as a predisposing factor of RM.
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.