Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 49 (9), 679-80

Candida Albicans Infection Inhibits Macrophage Cell Division and Proliferation


Candida Albicans Infection Inhibits Macrophage Cell Division and Proliferation

Leanne E Lewis et al. Fungal Genet Biol.


The pathogenicity of the opportunistic human fungal pathogen Candida albicans depends on its ability to inhibit effective destruction by host phagocytes. Using live cell video microscopy, we show here for the first time that C. albicans inhibits cell division in macrophages undergoing mitosis. Inhibition of macrophage cell division is dependent on the ability of C. albicans to form hyphae, as it is rarely observed following phagocytosis of UV-killed or morphogenesis-defective mutant Candida. Interestingly, failed cell division following phagocytosis of hyphal C. albicans is surprisingly common, and leads to the formation of large multinuclear macrophages. This raises question as to whether inhibition of macrophage cell division is another virulence attribute of C. albicans or enables host macrophages to contain the pathogen.

Similar articles

See all similar articles

Cited by 13 PubMed Central articles

See all "Cited by" articles


    1. Bain J.M., Lewis L.E., Okai B., Quinn J., Gow N.A.R., Erwig L.-P. Non-lytic expulsion/exocytosis of Candida albicans from macrophages. Fung. Genet Biol. 2012 - PMC - PubMed
    1. García-Rodas R., González-Camacho F., Rodríguez-Tudela J.L., Cuenca-Estrella M., Zaragoza O. The interaction between Candida krusei and murine macrophages results in multiple outcomes, including intracellular survival and escape from killing. Infect. Immun. 2011;79:2136–2144. - PMC - PubMed
    1. Gow N.A.R., van de Veerdonk F.L., Brown A.J.P., Netea M.G. Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat. Rev. Microbiol. 2012 - PMC - PubMed
    1. Greene W., Zhong G. Inhibition of host cell cytokinesis by Chlamydia trachomatis infection. J. Infect. 2003;47:45–51. - PubMed
    1. Lewis L.E., Bain J.M., Lowes C., Gillespie C., Rudkin F.M., Gow N.A.R., Erwig L.-P. Stage specific assessment of Candida albicans phagocytosis by macrophages identifies cell wall composition and morphogenesis as key determinants. PLoS Pathog. 2012;8(3):e1002578. - PMC - PubMed

Publication types