Human "orchestrator" CD11b(+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity

Mol Med. 2012 Sep 7;18(1):1003-8. doi: 10.2119/molmed.2012.00203.


Immune regulation produced by B cells has been attributed to production and secretion of interleukin (IL)-10, which is a characteristic of mouse B1 cells. In view of the widespread clinical use of B-cell depletion therapies in autoimmune and malignant diseases, it is important to monitor the function and fate of regulatory B cells. However, there is no consensus regarding the phenotypic identity of human IL-10(+) B cells. Here we show that human CD11b(+) B1 cells, one of two recently described subpopulations of B1 cells, spontaneously produce IL-10 and suppress T-cell activation. In view of the capacity of these B cells to either stimulate T-cell proliferation or suppress T-cell activation, CD11b(+) B1 cells are considered to be capable of orchestrating elements of immune responsiveness and thus are termed "orchestrator B1 cells," or "B1orc," whereas CD11b(-) B1 cells that primarily secrete antibody are termed "secretor B1 cells," or "B1sec."

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADP-ribosyl Cyclase 1 / metabolism
  • Adult
  • B-Lymphocytes / metabolism*
  • CD11b Antigen / metabolism*
  • CD24 Antigen / metabolism
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology
  • Humans
  • Interleukin-10 / metabolism*
  • Lymphocyte Activation / immunology
  • Membrane Glycoproteins / metabolism
  • Phenotype
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism


  • CD11b Antigen
  • CD24 Antigen
  • CD24 protein, human
  • IL10 protein, human
  • ITGAM protein, human
  • Membrane Glycoproteins
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Interleukin-10
  • CD38 protein, human
  • ADP-ribosyl Cyclase 1