The horizon for treating cutaneous vascular lesions

Semin Cutan Med Surg. 2012 Jun;31(2):98-104. doi: 10.1016/j.sder.2012.02.001.

Abstract

Dermatologists encounter a wide range of cutaneous vascular lesions, including infantile hemangiomas, port-wine stain birthmarks, arteriovenous malformations, venous malformations, Kaposi sarcomas, angiosarcomas, and angiofibromas. Current treatment modalities to reduce these lesions include topical and/or intralesional steroids, laser therapy, surgical resection, and endovascular therapy. However, each method has limitations owing to recurrence, comorbidities, toxicity, or lesion location. Photodynamic therapy, antiangiogenic therapy, and evolving methods of sclerotherapy are promising areas of development that may mitigate limitations of current treatments and offer exciting options for patients and their physicians.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiofibroma / therapy
  • Angiogenesis Inhibitors / therapeutic use
  • Arteriovenous Malformations / therapy
  • Hemangioma / therapy
  • Hemangiosarcoma / therapy
  • Humans
  • Laser Therapy
  • Low-Level Light Therapy
  • Photochemotherapy / methods
  • Photochemotherapy / trends
  • Port-Wine Stain / therapy
  • Sarcoma, Kaposi / therapy
  • Sclerotherapy / methods
  • Sclerotherapy / trends
  • Skin Diseases, Vascular / therapy*
  • Skin Neoplasms / therapy*

Substances

  • Angiogenesis Inhibitors