A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis

Mult Scler. 2013 Jan;19(1):69-75. doi: 10.1177/1352458512447870. Epub 2012 May 28.


Background: Magnetic resonance (MR) phase imaging using high field MR scanners has demonstrated excellent contrast in multiple sclerosis (MS) lesions that is thought to be closely correlated to the local iron content. This pilot study acquired serial in vivo MR scans at 7T to track the evolution of phase contrast as MS lesions progress.

Methods: Five MS patients with relapsing-remitting MS were serially scanned for about 2.5 years at 7T using a high resolution T2*-weighted gradient-echo sequence. Magnitude and phase images were reconstructed for each scan and co-registered to their baseline study.

Results: Five non-enhancing ring and 70 nodular phase lesions were found in the five patients at baseline. None of the baseline phase lesions (including all five ring phase lesions) showed obvious qualitative variation on phase images during the study. Of note, we observed that three magnitude lesions, not initially read as abnormal signal, were either better appreciated using phase contrast imaging (two lesions) or preceded (one lesion) by phase changes.

Conclusion: The observation that ring phase lesions remained unchanged over 2.5 years of follow-up challenges the notion that such lesions reveal the presence of acute activated iron-rich macrophages. It suggests that either different phenotypes of macrophages persist longer than previously expected or other mechanisms related to tissue injury contribute to the phase contrast.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / pathology*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / pathology*
  • Nerve Fibers, Myelinated / pathology*