7 Tesla MRI demonstrates vascular pathology in Balo's concentric sclerosis

Mult Scler. 2013 Jan;19(1):120-2. doi: 10.1177/1352458512445302. Epub 2012 May 28.


Baló's concentric sclerosis (BCS) is an inflammatory demyelinating disease related to multiple sclerosis; its underlying pathology remains unclear. At 7 T MRI in a 19-year-old female BCS patient, microhaemorrhages and ectatic veins were found in T2 hyperintense regions, features which have not been previously reported in conjunction with BCS, and these findings may support the view that vascular pathology plays a role in BCS. MRS data suggest that neuron loss and lipid turnover still took place months after a remission. Plasma exchange was effective in treating a relapse with severe motor deficits, and the off-label use of natalizumab was successful in maintaining remission in this patient.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Brain / pathology
  • Diffuse Cerebral Sclerosis of Schilder / pathology*
  • Female
  • Humans
  • Immunologic Factors / therapeutic use
  • Magnetic Resonance Imaging / methods*
  • Natalizumab
  • Young Adult


  • Antibodies, Monoclonal, Humanized
  • Immunologic Factors
  • Natalizumab