Found in translation of mTOR signaling

Cell Res. 2012 Sep;22(9):1315-8. doi: 10.1038/cr.2012.85. Epub 2012 May 29.

Abstract

The mammalian target of rapamycin (mTOR) protein kinase regulates a wide variety of cellular processes, including protein synthesis, yet the downstream translational program under the control of mTOR is poorly understood. Two recent studies by Hsieh et al. and Thoreen et al. now start to address this issue, and uncover a subset of genes translationally regulated by oncogenic mTOR signaling that may contribute to tumorigenesis.

MeSH terms

  • Animals
  • Down-Regulation / drug effects
  • Eukaryotic Initiation Factors / metabolism
  • Humans
  • Indoles / pharmacology
  • Mice
  • Naphthyridines / pharmacology
  • Protein Kinase Inhibitors / pharmacology
  • Purines / pharmacology
  • RNA, Messenger / metabolism
  • Signal Transduction
  • TOR Serine-Threonine Kinases / antagonists & inhibitors
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one
  • Eukaryotic Initiation Factors
  • Indoles
  • Naphthyridines
  • Protein Kinase Inhibitors
  • Purines
  • RNA, Messenger
  • TOR Serine-Threonine Kinases
  • PP242