Perspectives on: SGP symposium on mitochondrial physiology and medicine: metabolic homeostasis of the heart

doi:10.1085/jgp.201210783

Review

. 2012 Jun;139(6):407-14.

doi: 10.1085/jgp.201210783.

Perspectives on: SGP symposium on mitochondrial physiology and medicine: metabolic homeostasis of the heart

Robert S Balaban¹

Affiliations

PMID: 22641635
PMCID: PMC3362523
DOI: 10.1085/jgp.201210783

Review

Perspectives on: SGP symposium on mitochondrial physiology and medicine: metabolic homeostasis of the heart

Robert S Balaban. J Gen Physiol. 2012 Jun.

. 2012 Jun;139(6):407-14.

doi: 10.1085/jgp.201210783.

Author

Robert S Balaban¹

Affiliation

¹ Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20817, USA. rsb@nih.gov

PMID: 22641635
PMCID: PMC3362523
DOI: 10.1085/jgp.201210783

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Figures

**Figure 1.**
Michaelis–Menten model for ADP driving ATP production at maximum Pi values. Each colored line represents a different V_max for the reaction. The V_max values are listed at the end of each curve. The green line represents a constant homeostatic ADP concentration.

See this image and copyright information in PMC

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References

1. Acin-Perez R., Gatti D.L., Bai Y., Manfredi G. 2011. Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Cell Metab. 13:712–719 10.1016/j.cmet.2011.03.024 - DOI - PMC - PubMed
1. Antico Arciuch V.G., Alippe Y., Carreras M.C., Poderoso J.J. 2009. Mitochondrial kinases in cell signaling: Facts and perspectives. Adv. Drug Deliv. Rev. 61:1234–1249 10.1016/j.addr.2009.04.025 - DOI - PubMed
1. Aponte A.M., Phillips D., Hopper R.K., Johnson D.T., Harris R.A., Blinova K., Boja E.S., French S., Balaban R.S. 2009. Use of (32)P to study dynamics of the mitochondrial phosphoproteome. J. Proteome Res. 8:2679–2695 10.1021/pr800913j - DOI - PMC - PubMed
1. Balaban R.S. 2002. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J. Mol. Cell. Cardiol. 34:1259–1271 10.1006/jmcc.2002.2082 - DOI - PubMed
1. Balaban R.S., Kantor H.L., Katz L.A., Briggs R.W. 1986. Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science. 232:1121–1123 10.1126/science.3704638 - DOI - PubMed

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[1] Acin-Perez R., Gatti D.L., Bai Y., Manfredi G. 2011. Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Cell Metab. 13:712–719 10.1016/j.cmet.2011.03.024 - DOI - PMC - PubMed

[2] Acin-Perez R., Gatti D.L., Bai Y., Manfredi G. 2011. Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Cell Metab. 13:712–719 10.1016/j.cmet.2011.03.024 - DOI - PMC - PubMed

[3] Antico Arciuch V.G., Alippe Y., Carreras M.C., Poderoso J.J. 2009. Mitochondrial kinases in cell signaling: Facts and perspectives. Adv. Drug Deliv. Rev. 61:1234–1249 10.1016/j.addr.2009.04.025 - DOI - PubMed

[4] Antico Arciuch V.G., Alippe Y., Carreras M.C., Poderoso J.J. 2009. Mitochondrial kinases in cell signaling: Facts and perspectives. Adv. Drug Deliv. Rev. 61:1234–1249 10.1016/j.addr.2009.04.025 - DOI - PubMed

[5] Aponte A.M., Phillips D., Hopper R.K., Johnson D.T., Harris R.A., Blinova K., Boja E.S., French S., Balaban R.S. 2009. Use of (32)P to study dynamics of the mitochondrial phosphoproteome. J. Proteome Res. 8:2679–2695 10.1021/pr800913j - DOI - PMC - PubMed

[6] Aponte A.M., Phillips D., Hopper R.K., Johnson D.T., Harris R.A., Blinova K., Boja E.S., French S., Balaban R.S. 2009. Use of (32)P to study dynamics of the mitochondrial phosphoproteome. J. Proteome Res. 8:2679–2695 10.1021/pr800913j - DOI - PMC - PubMed

[7] Balaban R.S. 2002. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J. Mol. Cell. Cardiol. 34:1259–1271 10.1006/jmcc.2002.2082 - DOI - PubMed

[8] Balaban R.S. 2002. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J. Mol. Cell. Cardiol. 34:1259–1271 10.1006/jmcc.2002.2082 - DOI - PubMed

[9] Balaban R.S., Kantor H.L., Katz L.A., Briggs R.W. 1986. Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science. 232:1121–1123 10.1126/science.3704638 - DOI - PubMed

[10] Balaban R.S., Kantor H.L., Katz L.A., Briggs R.W. 1986. Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science. 232:1121–1123 10.1126/science.3704638 - DOI - PubMed

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Perspectives on: SGP symposium on mitochondrial physiology and medicine: metabolic homeostasis of the heart

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Perspectives on: SGP symposium on mitochondrial physiology and medicine: metabolic homeostasis of the heart

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