Prognosis and prognostic factors of patients with mesothelioma: a population-based study

Br J Cancer. 2012 Jun 26;107(1):161-4. doi: 10.1038/bjc.2012.245. Epub 2012 May 29.


Background: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management.

Methods: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008.

Results: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR=1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR=2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR=1.67 95% CI (1.26-2.22)).

Conclusion: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Mesothelioma / diagnosis*
  • Mesothelioma / mortality
  • Middle Aged
  • Netherlands / epidemiology
  • Pleural Neoplasms / diagnosis
  • Pleural Neoplasms / mortality
  • Population Surveillance
  • Prognosis
  • Risk Factors
  • Survival Analysis