Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative

Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6452-5. doi: 10.1002/anie.201202383. Epub 2012 May 29.


It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation on irradiation with violet (407 nm) and green (500-550 nm) light (see picture) through isomerization of the cross-linker. The large separation of the absorbance bands of the cis (yellow) and trans (red) isomers enables complete bidirectional photoswitching.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry*
  • Models, Molecular
  • Peptides / chemistry*
  • Photochemical Processes*
  • Protein Structure, Tertiary


  • Azo Compounds
  • Peptides
  • azobenzene