Abstract
The inhibition of Interleukin-1beta (IL-1β) is of substantial interest for the treatment of rheumatoid arthritis. Using an in vitro assay with RAW 264.7 cells, oxo-acetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester (1) was isolated from the roots of Paeonia suffruticosa Andrews as an inhibitor of IL-1β with an IC(50) value of 56 μM. Compound 1 is a novel phenylesteric compound from P. suffruticosa Andrews. Compound 1 was shown to inhibit the production of pro-inflammatory cytokines in RAW 264.7 cells. Thus, a possible new action of novel compound is provided explaining the anti-rheumatoid arthritic properties of P. suffruticosa Andrews.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Acetates / isolation & purification*
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Acetates / pharmacology*
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Acetic Acid / chemistry
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Acetic Acid / isolation & purification
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Acetic Acid / pharmacology
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Acetone / analogs & derivatives*
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Acetone / chemistry
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Acetone / isolation & purification
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Acetone / pharmacology
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Animals
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Antirheumatic Agents / chemistry
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Antirheumatic Agents / isolation & purification
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Antirheumatic Agents / pharmacology
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Cell Line
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / isolation & purification*
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Immunosuppressive Agents / pharmacology*
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Interleukin-1beta / antagonists & inhibitors*
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Interleukin-1beta / physiology
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Mice
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Paeonia*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology*
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Plant Roots*
Substances
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Acetates
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Antirheumatic Agents
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Immunosuppressive Agents
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Interleukin-1beta
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Plant Extracts
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oxoacetic acid 2-ethoxy-4-(3-hydroxy-2-oxopropyl) phenyl ester
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Acetone
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Acetic Acid