Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats

ScientificWorldJournal. 2012;2012:941685. doi: 10.1100/2012/941685. Epub 2012 May 3.

Abstract

This paper shows a new finding about the decrease of relaxative response to loperamide in prostate of spontaneously hypertensive rats (SHR) as compare to normal rats (WKY). Authors demonstrated the reduction of ATP-sensitive potassium channels is responsible for this change using immunoblotting analysis and the decrease of action induced by diazoxide. This view is not mentioned before and is the first one reporting this result.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Animals
  • Antidiarrheals / pharmacology
  • Diazoxide / chemistry
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation / drug effects
  • KATP Channels / chemistry
  • Loperamide / pharmacology*
  • Male
  • Potassium Channels / chemistry
  • Potassium Channels, Inwardly Rectifying / chemistry
  • Prostate / drug effects*
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Receptors, Opioid / metabolism
  • Receptors, Opioid, mu / chemistry
  • Temperature

Substances

  • Antidiarrheals
  • KATP Channels
  • Kir6.2 channel
  • Potassium Channels
  • Potassium Channels, Inwardly Rectifying
  • Receptors, Opioid
  • Receptors, Opioid, mu
  • Loperamide
  • Adenosine Triphosphate
  • Diazoxide