Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial

Mol Nutr Food Res. 2012 May;56(5):810-21. doi: 10.1002/mnfr.201100673.


Scope: The cardioprotective role of resveratrol as part of the human diet is not yet clear. Our aim was to investigate the effect of a grape supplement containing 8 mg resveratrol in oxidized LDL (LDLox), apolipoprotein-B (ApoB), and serum lipids on statin-treated patients in primary cardiovascular disease prevention (PCP).

Methods and results: A triple-blind, randomized, placebo-controlled trial was conducted. Seventy-five patients (three parallel arms) consumed one capsule (350 mg) daily for 6 months containing resveratrol-enriched grape extract (GE-RES, Stilvid®), grape extract (GE, similar polyphenolic content but no resveratrol), or placebo (maltodextrin). After 6 months, no changes were observed in the placebo group and only LDL cholesterol (LDLc) decreased by 2.9% (p = 0.013) in the GE group. In contrast, LDLc (-4.5%, p = 0.04), ApoB (-9.8%, p = 0.014), LDLox (-20%, p = 0.001), and LDLox/ApoB (-12.5%, p = 0.000) decreased in the Stilvid® group, whereas the ratio non-HDLc (total atherogenic cholesterol load)/ApoB increased (8.5%, p = 0.046). No changes were observed in hepatic, thyroid, and renal function. No adverse effects were observed in any of the patients.

Conclusion: This GE-RES reduced atherogenic markers and might exert additional cardioprotection beyond the gold-standard medication in patients from PCP. The presence of resveratrol in the GE was necessary to achieve these effects.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Apolipoproteins B / blood*
  • Cardiovascular Diseases / prevention & control*
  • Dietary Supplements*
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney / drug effects
  • Kidney / physiology
  • Lipids / blood
  • Lipoproteins, LDL / blood*
  • Liver / drug effects
  • Liver / physiology
  • Male
  • Middle Aged
  • Plant Extracts / pharmacology
  • Resveratrol
  • Stilbenes / pharmacology*
  • Thyroid Function Tests
  • Vitis / chemistry


  • Apolipoproteins B
  • Lipids
  • Lipoproteins, LDL
  • Plant Extracts
  • Stilbenes
  • oxidized low density lipoprotein
  • Resveratrol