Abstract
Heterotrimeric guanine nucleotide-binding proteins (G proteins) are positioned at the top of many signal transduction pathways. The G protein α subunit is composed of two domains, one that resembles Ras and another that is composed entirely of α helices. Historically most attention has focused on the Ras-like domain, but emerging evidence reveals that the helical domain is an active participant in G protein signaling.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Enzyme Activation / physiology
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GTP-Binding Protein alpha Subunits / chemistry*
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GTP-Binding Protein alpha Subunits / genetics
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GTP-Binding Protein alpha Subunits / metabolism*
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Humans
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Oncogene Protein p21(ras) / chemistry
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Oncogene Protein p21(ras) / genetics
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Oncogene Protein p21(ras) / metabolism
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Signal Transduction / physiology*
Substances
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GTP-Binding Protein alpha Subunits
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Oncogene Protein p21(ras)