Serum uric acid levels are associated with atrial fibrillation in patients with ischemic heart failure

Angiology. 2013 May;64(4):300-3. doi: 10.1177/0003319712448247. Epub 2012 May 30.


We evaluated the association between serum uric acid (SUA) and atrial fibrillation (AF) in patients with chronic heart failure (HF). Totally, 363 patients with chronic HF were included in the study. Of all, 78 patients had AF and 285 patients were in normal sinus rhythm. Serum uric acid was significantly increased in patients with AF compared with patients in normal sinus rhythm (P < .05). Comparing patients with AF and normal sinus rhythm, we found that age was significantly higher in patients group with AF. Echocardiographic parameters including ejection fraction, left atrial diameter, left ventricle end-diastolic diameter, and left ventricle end-diastolic volume were also significantly higher in patients with AF compared with patients in normal sinus rhythm. We have shown that patients with AF have significantly higher SUA and this was independently associated with AF in patients with ischemic HF.

MeSH terms

  • Aged
  • Atrial Fibrillation / blood
  • Atrial Fibrillation / diagnosis
  • Atrial Fibrillation / etiology*
  • Atrial Fibrillation / physiopathology
  • Biomarkers / blood
  • Chronic Disease
  • Female
  • Heart Atria / diagnostic imaging
  • Heart Failure / blood
  • Heart Failure / diagnosis
  • Heart Failure / etiology*
  • Heart Failure / physiopathology
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Myocardial Ischemia / complications*
  • Retrospective Studies
  • Risk Factors
  • Stroke Volume
  • Ultrasonography
  • Up-Regulation
  • Uric Acid / blood*
  • Ventricular Function, Left


  • Biomarkers
  • Uric Acid