Effects of halothane, enflurane and isoflurane anaesthesia on renal plasma flow

Br J Anaesth. 1990 Dec;65(6):796-800. doi: 10.1093/bja/65.6.796.


Effective renal plasma flow (ERPF) and linear cardiac output (aortic blood velocity) were measured in 15 patients who received halothane, enflurane or isoflurane in oxygen. All three agents caused a significant reduction in ERPF (P less than 0.05) and the effect was greater at 1.25 MAC than at 0.75 MAC. No significant difference was demonstrated between the agents. Linear cardiac output did not change significantly during the study, suggesting that the observed reduction in ERPF was not caused by cardiovascular depression.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anesthesia, Inhalation*
  • Cardiac Output
  • Enflurane / pharmacology*
  • Halothane / pharmacology*
  • Humans
  • Isoflurane / pharmacology*
  • Middle Aged
  • Renal Circulation / drug effects*


  • Enflurane
  • Isoflurane
  • Halothane