Massive histamine release in a patient with systemic mastocytosis

J P Desborough; I Taylor; A Hattersley; A Garden; A Wolff; S R Bloom; M Morgan

doi:10.1093/bja/65.6.833

Massive histamine release in a patient with systemic mastocytosis

Br J Anaesth. 1990 Dec;65(6):833-6. doi: 10.1093/bja/65.6.833.

Authors

J P Desborough¹, I Taylor, A Hattersley, A Garden, A Wolff, S R Bloom, M Morgan

Affiliation

¹ Department of Anesthestic, Royal Postgraduate Medical School, Hammersmith Hospital, London.

PMID: 2265056
DOI: 10.1093/bja/65.6.833

Abstract

We have measured plasma histamine concentrations, systemic vascular resistance, cardiac output and arterial pressure during laparotomy in a patient with systemic mastocytosis. The patient developed vasodilation and hypotension during surgery, associated with a massive increase in plasma histamine concentration.

Publication types

Case Reports

MeSH terms

Anesthesia, General
Blood Pressure
Cardiac Output
Histamine / blood*
Humans
Hypotension / etiology*
Intraoperative Complications / etiology
Laparotomy
Male
Mastocytosis / blood*
Mastocytosis / physiopathology
Middle Aged
Shock / etiology*
Vascular Resistance

Substances

Histamine