Topical and systemic therapies for nickel allergy

Dermatitis. Sep-Oct 2011;22(5):251-5. doi: 10.2310/6620.2011.11015.

Abstract

Nickel allergy can result in both cutaneous and systemic manifestations, and can range from mild to severe symptoms. A severe form of this allergy is the Systemic nickel allergy syndrome, clinically characterized by cutaneous manifestions (contact dermatitis, pompholyx, hand dermatitis dyshydrosis, urticaria) with chronic course and systemic symptoms (headache, asthenia, itching, and gastrointestinal disorders related to histopathological alterations of gastrointestinal mucosa, borderline with celiac disease). This review aims to briefly update the reader on past and current therapies for nickel contact allergy.

Publication types

  • Review

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Adrenal Cortex Hormones / administration & dosage
  • Anti-Inflammatory Agents / administration & dosage
  • Dermatitis, Allergic Contact / etiology
  • Dermatitis, Allergic Contact / therapy*
  • Diet Therapy / methods
  • Disulfiram / administration & dosage
  • Emollients / administration & dosage
  • Enzyme Inhibitors / administration & dosage
  • Humans
  • Hypersensitivity / etiology*
  • Hypersensitivity / therapy
  • Nickel / adverse effects*
  • Phototherapy / methods
  • Randomized Controlled Trials as Topic
  • Zinc / administration & dosage

Substances

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Emollients
  • Enzyme Inhibitors
  • Nickel
  • Zinc
  • Disulfiram