Isolation and characterization of the transferrin receptor from human placenta

J Biol Chem. 1979 Oct 25;254(20):9943-6.

Abstract

The transferrin receptor has been isolated from human placenta using immunochromatography and affinity chromatography. The receptor is a glycoprotein and has a Mr = 90,000 on sodium dodecyl sulfate-gel electrophoresis in the presence of 2-mercaptoethanol. The isolated receptor is immunologically related to the transferrin receptor on the reticulocyte cell surface.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / analysis
  • Carbohydrates / analysis
  • Cell Membrane / metabolism
  • Female
  • Glycoproteins / isolation & purification
  • Glycoproteins / metabolism
  • Humans
  • Immunodiffusion
  • Molecular Weight
  • Placenta / metabolism*
  • Pregnancy
  • Receptors, Cell Surface / isolation & purification*
  • Receptors, Cell Surface / metabolism
  • Reticulocytes / metabolism
  • Transferrin / metabolism*

Substances

  • Amino Acids
  • Carbohydrates
  • Glycoproteins
  • Receptors, Cell Surface
  • Transferrin