Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential

Acta Biomater. 2012 Sep;8(9):3270-82. doi: 10.1016/j.actbio.2012.05.031. Epub 2012 May 29.


The design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol-gel chemical route; these compounds possess flexible Si-O-Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomyces / drug effects
  • Animals
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / pharmacology
  • Candida albicans / drug effects
  • Flow Cytometry
  • Magnetic Resonance Spectroscopy
  • Methacrylates / chemistry*
  • Methacrylates / pharmacology
  • Mice
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Quaternary Ammonium Compounds / chemistry*
  • Silanes / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Streptococcus mutans / drug effects
  • Thermogravimetry


  • Anti-Infective Agents
  • Methacrylates
  • Quaternary Ammonium Compounds
  • Silanes