Megaesophagus attributable to lead toxicosis was diagnosed in a 3-year-old spayed domestic shorthair cat. The cat regurgitated when it was distressed by handling, and there was clinical evidence of laryngeal and pharyngeal dysfunction. The cat had macrocytic regenerative anemia, but did not have normoblastosis or basophilic stippling of RBC. The megaesophagus, pharyngeal/laryngeal dysfunction, and anemia resolved with calcium EDTA treatment.