Psoriasis: evolving treatment for a complex disease

Cleve Clin J Med. 2012 Jun;79(6):413-23. doi: 10.3949/ccjm.79a.11133.


The cutaneous manifestations of psoriasis can vary in morphology and severity, and therapy should be tailored accordingly. Biologic agents are important new options for treating patients with the most severe forms of the disease. All physicians should be aware that severe psoriasis may increase cardiovascular morbidity and the risk of death, and preventive strategies for patients with severe disease should be considered.

Publication types

  • Review

MeSH terms

  • Humans
  • Keratinocytes / physiology
  • Psoriasis / complications
  • Psoriasis / drug therapy*
  • Psoriasis / physiopathology
  • Severity of Illness Index
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*


  • Tumor Necrosis Factor-alpha