Risk factors for primary open-angle glaucoma in South Korea: the Namil study

Jpn J Ophthalmol. 2012 Jul;56(4):324-9. doi: 10.1007/s10384-012-0153-4. Epub 2012 Jun 5.


Purpose: To investigate the risk factors for primary open-angle glaucoma (POAG) in the Namil study population.

Methods: A cross-sectional, population-based epidemiological study of residents aged ≥40 years from Namil-myon, South Korea, was conducted. Fifty-five subjects with POAG and 1,409 controls were enrolled in this study. Univariate and multivariate logistic regression analyses were performed to identify ocular and systemic factors associated with POAG.

Results: Multivariate logistic regression analysis demonstrated that older age, a history of thyroid disease and higher IOP were associated with an increased risk of POAG. Subgroup analysis showed that older age (OR 1.033, 95 % CI 1.003-1.063 per year), a history of thyroid disease (OR 7.373, 95 % CI 1.407-38.636) and higher IOP (OR 1.132, 95 % CI 1.011-1.268 per mmHg) were risk factors for normal tension glaucoma (NTG, POAG with IOP ≤21 mmHg).

Conclusions: In the Namil study, higher IOP, older age and a history of thyroid disease were significant risk factors for POAG.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Epidemiologic Studies
  • Female
  • Glaucoma, Open-Angle / diagnosis
  • Glaucoma, Open-Angle / epidemiology*
  • Humans
  • Intraocular Pressure / physiology
  • Low Tension Glaucoma / diagnosis
  • Low Tension Glaucoma / epidemiology
  • Male
  • Middle Aged
  • Odds Ratio
  • Republic of Korea / epidemiology
  • Risk Factors
  • Visual Field Tests
  • Visual Fields / physiology