Critical evaluation of the efficacy and tolerability of azilsartan

Vasc Health Risk Manag. 2012:8:299-305. doi: 10.2147/VHRM.S22589. Epub 2012 May 14.

Abstract

Appropriate control of blood pressure (BP) in hypertensive patients still represents the major therapeutic goal in the treatment of hypertension. Despite the growing attention and wide range of antihypertensive agents available in the clinical scenario, the target of BP below the advised thresholds of 140/90 mmHg is, unfortunately, often unreached. For this reason, the search for new antihypertensive agents is still ongoing. Azilsartan medoxomil, a new angiotensin receptor blocker that has been recently introduced in the clinical arena, represents the eighth angiotensin receptor blocker currently available for BP control. The aim of this paper is to describe the efficacy and safety profile of this new compound, reviewing available data obtained from both pre-clinical and clinical studies.

Keywords: angiotensin receptor blocker; azilsartan medoxomil; hypertension.

Publication types

  • Review

MeSH terms

  • Angiotensin II Type 1 Receptor Blockers / adverse effects
  • Angiotensin II Type 1 Receptor Blockers / pharmacokinetics
  • Angiotensin II Type 1 Receptor Blockers / therapeutic use*
  • Animals
  • Antihypertensive Agents / adverse effects
  • Antihypertensive Agents / pharmacokinetics
  • Antihypertensive Agents / therapeutic use*
  • Benzimidazoles / adverse effects
  • Benzimidazoles / pharmacokinetics
  • Benzimidazoles / therapeutic use*
  • Blood Pressure / drug effects*
  • Drug Interactions
  • Evidence-Based Medicine
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Oxadiazoles / adverse effects
  • Oxadiazoles / pharmacokinetics
  • Oxadiazoles / therapeutic use*
  • Renin-Angiotensin System / drug effects
  • Risk Assessment
  • Treatment Outcome

Substances

  • Angiotensin II Type 1 Receptor Blockers
  • Antihypertensive Agents
  • Benzimidazoles
  • Oxadiazoles
  • azilsartan
  • azilsartan medoxomil