A prospective comparison of rubidium-82 PET and thallium-201 SPECT myocardial perfusion imaging utilizing a single dipyridamole stress in the diagnosis of coronary artery disease

J Nucl Med. 1990 Dec;31(12):1899-905.


The purpose of the present study is to prospectively compare myocardial perfusion imaging with rubidium-82 (82Rb) by positron emission tomography (PET) with thallium-201 (201Tl) imaging by single-photon emission tomography (SPECT) by recording both studies with a single dipyridamole handgrip stress, and reading both sets of images with the same display technique. In a series of 202 patients with previous coronary arteriography, the sensitivity, specificity, and accuracy of 82Rb PET were 93%, 78%, and 90% and for 201Tl SPECT 76%, 80%, and 77%, respectively. When 70 patients with previous therapeutic interventions were excluded, the remaining 132 patients showed a sensitivity, specificity, and accuracy of 95%, 82% and 92% for 82Rb PET and 79%, 76%, and 78% for 201Tl SPECT. The improved contrast resolution of PET resulted in markedly superior images and a more confident identification of defects.

Publication types

  • Comparative Study

MeSH terms

  • Coronary Circulation / physiology*
  • Coronary Disease / diagnostic imaging*
  • Coronary Disease / epidemiology
  • Coronary Disease / physiopathology
  • Dipyridamole
  • False Negative Reactions
  • False Positive Reactions
  • Humans
  • Image Processing, Computer-Assisted
  • Prospective Studies
  • Rubidium Radioisotopes*
  • Sensitivity and Specificity
  • Thallium Radioisotopes*
  • Tomography, Emission-Computed*
  • Tomography, Emission-Computed, Single-Photon*


  • Rubidium Radioisotopes
  • Thallium Radioisotopes
  • Dipyridamole