Tumor-specific MAGE proteins as regulators of p53 function

Cancer Lett. 2012 Dec 1;325(1):11-7. doi: 10.1016/j.canlet.2012.05.031. Epub 2012 Jun 1.

Abstract

Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Growth Processes / physiology
  • Humans
  • Melanoma / genetics*
  • Melanoma / metabolism*
  • Melanoma-Specific Antigens / genetics*
  • Melanoma-Specific Antigens / metabolism*
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Melanoma-Specific Antigens
  • Tumor Suppressor Protein p53