Effects of peripheral administration of recombinant human interleukin-1 beta on feeding behavior of the rat

Life Sci. 1990;47(24):2185-92. doi: 10.1016/0024-3205(90)90148-k.


This study was undertaken to investigate the changes in feeding behavior, including ambulatory activity, induced by a single injection of Interleukin-1 beta (IL-1) (2 micrograms/rat) at 18:00, just before the dark phase. For this purpose, we used the Gunma University-type automatic apparatus for continuous and direct measurement of ambulation and drinking. A significant decrease in food intake was observed for 12 hours after treatment with IL-1. Peripheral administration of IL-1 also produced a marked decrease in ambulatory activity within 3 hours which continued for 6 hours. In addition, IL-1 produced a marked decrease in drinking behavior during the first 6 hours. We reported here the changes in consummatory and ambulatory behavior of rats after acute administration of IL-1. The sickness which IL-1 produced may, at least in part, contribute to these phenomena, although precise mechanisms are still unknown.

MeSH terms

  • Animals
  • Circadian Rhythm / drug effects
  • Drinking Behavior / drug effects
  • Feeding Behavior / drug effects*
  • Injections, Intraperitoneal
  • Interleukin-1 / administration & dosage
  • Interleukin-1 / pharmacology*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / pharmacology


  • Interleukin-1
  • Recombinant Proteins