Clinical evaluation of allicin oral adhesive tablets in the treatment of recurrent aphthous ulceration

Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Apr;113(4):500-4. doi: 10.1016/j.oooo.2011.09.007.


Objective: We investigated the effectiveness and safety of topical application of 5 mg allicin adhesive tablets in the treatment of minor recurrent aphthous ulcerations (MiRAU).

Material and methods: A randomized, double-blinded, placebo-controlled, clinical trial was performed. Tablets containing 5 mg allicin or vehicle only were consecutively applied 4 times per day for 5 days. The size and pain level of ulcers were measured and recorded on days 1, 2, 4, and 6.

Results: A total of 96 subjects with MiRAU fulfilled the study. Allicin adhesive tablets significantly reduced ulcer size (P < .005, P < .003, P < .001 for days 2, 4, and 6, respectively) and alleviated ulcer pain score (P < .03, P < .001, P < .05 for days 2, 4, and 6, respectively) compared with vehicle tablets. Minor and major adverse reactions were not observed.

Conclusions: Allicin adhesive tablets were effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of MiRAU without significant side effects.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesives / therapeutic use*
  • Adolescent
  • Adult
  • Chi-Square Distribution
  • Female
  • Humans
  • Male
  • Middle Aged
  • Statistics, Nonparametric
  • Stomatitis, Aphthous / drug therapy*
  • Sulfinic Acids / therapeutic use*
  • Tablets
  • Treatment Outcome
  • Young Adult


  • Adhesives
  • Sulfinic Acids
  • Tablets
  • allicin